I think this song is about when you keep your eyes open, know way too much about the things around you, and thanks to this you have great control over the events, you're in safe so much, but this blocks you from going into a lot of situations, when you know there could be a bad outcome. It's about the power and protection that information gives, but also the drawbacks.

"My guilt and my shame
Always sell me short, always feel the same
And my face and my soul
Always wear me thin, always under control"

When something bad happens you knew that it may happen, but you kept the information's hidden (if it could've been just oil to the fire), you feel terrible guilt. Also, when you encounter a situation when you know a possible bad outcome, you retreat, and rather become ashamed in front of others by playing coward with ridiculous excuses, than explaining them your reasons. With these things, you keep your real emotions inside, others never know you knew something before, or that you have a very strong reason to not to do something.

"But the longest hours you'll have in your life
Are the ones you sit through to know if you're right
So I'll wait but I pray that I'm wrong
Because I think I know what's going on"

When something serious happens with no explanation but you know something suspicios about it, you assemble an often dark picture in your mind, and you know that it may be the truth. Later, when you gain additional information, or events happen, that could lead to prove your theory, you feel nervous waiting for the moment of the truth.

"So let me get this straight
The only will is my own
I do whatever I want and stay alone
All my decisions make it untouchable and tainted"

Here in the song you start to expose the real yourself to someone.
It's about that you have enough power (knowledge) to control everything around you, if you want something to happen then it will happen soon, and if you really decide something noone will be able to override it.

"I'm gonna suffer for the rest of my life
But I will always find a way to survive
I'm not a failure but I know what it's like
I can take it or leave it or die"

You will always suffer under the weight of your knowledge, because something you know prevents you to be really yourself in the most of the situations, you see a lot of possible danger in the world, so you miss a lot of chances rather than taking the risk. It's not cowardice, because you know very strong reasons to not to do something, you previously may learned from the mistakes of others in the same situation, or you know yourself enough to know that you have a bigger chance of failing, than succeeding, and you know in that situation failing will be fatal. But the other side of this is that you always know enough to safely escape from extreme situations, and rarely you may know that a certain danger may not apply to you, and you can take some very risky thing with no real risk. You don't consider your life a failure, becuase you always know your opportunities and always have a wide range of choices, but as explained above, you often rather fail smaller things in exchange for not risking the failing of bigger things.

"Stay, you don't always know where you stand
Till you know that you won't run away
There's something inside me that feels
Like breathing in sulfur"

It's the unleashing of the real yourself again, giving advise to someone else to reconsider things, and decide only after that, because you know something important, and it may cause problems if that someone decides too hastily, ignoring the information you know. At that time, you feel something strange, you feel your hidden emotions breaking out.

"My life is undone
And I'm a sinner to most but a sage to some
And my Gods are untrue
I'm probably wrong but I'm better than you"

It's about that your life may be fucked up, and most could think that you're wrong, but you know that you made your choices considering everything at the moment, trying to get the best out of the bad situations, and the most secure out of the unsure situations. You are better than the person you talk to, because he/she may have a better life, but could had even better by making more deliberate decisions.

"And the longest hours I've had in my life
Were the ones I went through to know I was right
So I'm safe but I'm a little outside
I'm gonna laugh when I'm buried alive"

Now you tell, that you guessed the truth right in a lot of cases, you have so much knowledge and done a lot of things to be safe in more and more previously dangerous situations, but you feel you became distant from others. Also, you tell that there's a lot of things that others still don't know about you, and you will laugh when they will falsely think that you're in some big trouble, but actually at that time things will be completely under your control.